ABSTRACT
Background@#Globally the incidence of stroke is not decreasing, and the deaths and disabilities caused by stroke is increasing every year, especially in low and low-middle income countries.</br> Long-term trends in stroke incidence in different populations have not been well characterized, largely as a result of the complexities associated with population-based stroke surveillance.</br> Having reliable data on stroke morbidity and mortality, as well as periodic identification of long-term trends will be important information for proper prevention planning in the population, monitoring the disease and further improving the quality of health care. @*Material and Method@#A prospective cohort study has been conducted in adult citizens (972409 in 2019, 925367 in 2020) of 6 districts of Ulaanbaatar from the 1st of January, 2019 to 31st of December, 2020. All first-ever and recurrent stroke cases were included using special software, developed for stroke registry, based on the WHO STEPS approach from participating radiology departments of state hospitals, district hospitals, and some private hospitals. Information of stroke death was obtained from forensic institute and state registration office of the capital city.</br> The trends of stroke incidence and mortality was compared to data between 1998-1999 and 2019- 2020 in UB. @*Results@#The age-standardized crude incidence rate per 100.000 person-years of stroke were 209.0/100.000 (n=1934) in 2019 and 194.0/100.000 (n=1821) in 2020 among adults of UB city. The above results were compared to 1998-1999 studies and the incidence rate declined by 94.0/100.000 in 2019-2020, whereas mortality rate increased by 10.0/100.000 in women aged 16-34. Stroke mortality was 11.6% in 1998 and 26.5% in 1999, while in our study it was 33.87% in 2019 and 29.71% in 2020. Although the incidence of stroke rates has decreased in 1998-1999, the mortality rate has not decreased significantly. @*Conclusion@#Morbidity and mortality rates among the population of Ulaanbaatar citizen remain highest in the world, compared to 20 years ago with overall morbidity declining but mortality has not decreased. </br> In recent years, the Government of Mongolia has been focused on reducing non-communicable diseases, but the primary and secondary prevention and control of stroke in the general population, as well as the acquisition of knowledge attitudes, practices and access to health care still need to be improved.
ABSTRACT
Background@#Stroke is still one of the leading causes of morbidity and mortality worldwide. Registry-based data of stroke are scarce in low and middle-income countries such as Mongolia. We aimed to investigate the incidence and mortality of stroke in adult population of UB Mongolia by stroke registration method. @*Material and Method@#Covering 611265 (≥15 years old) adult citizens of three districts of Ulaanbaatar, a population-based prospective study was done from the first, January of 2019 to 31st, December of 2019. All first-ever and recurrent stroke cases were included using special software, developed for stroke registry, based on the WHO STEPS approach from participating radiology departments of state hospitals, district hospitals, and family clinics. Information of stroke death was obtained from forensic institute and state registration office of the capital city. @*Results @#In a 1-year study period, 1068 (women 39.1%) stroke cases were registered in people with 60.16±13.66 years old. Stroke incidence rate was 169.81/100000 including first-ever and recurrent events. Stroke incidence rate was higher in men and people with 80 and above years old. The ratio between IS and ICH was 1.14:1.0. Stroke mortality was 27.1% and mortality rate was 45.94/100000. The highest rate mortality was in ICH subtype, male population and older people. @*Conclusion@#We identified relatively high incidence and mortality rate of stroke in ICH indicating an urgent need for improvement of arterial hypertension control, health education and primary prevention mainly among men.
ABSTRACT
PUR POSE The aim of the present study was to determine the effective dose of Carbamazepine . according to the serum level concentration. ° METHODS 20 patients with symptomatic focal epilepsy: 10 males and 10 females included in the study. The average age was 3I.8± 8.9 (range 16-50 years).The mean duration of partial seizure was 11.4 ±5.8 years. All patients were using inappropriate doses of Carbamazepine and most of patients were taking it irregularly. Patients were follow- upped during 3 months. Initial dose of treatment was 9.4 ± 2.2 mg/kg. Pharmacokinetic analysis was performed by ABBOTT TDXFLX immunofluorescence autoanalyser in the Laboratory department of the Central Clinical Hospital. The blood samples were collected from patients in the morning before taking the morning dose and after 2 hours. RESULTS Therapeutic effective serum level of Carbamazepine in 8 seizure free patients (40%) was 8.25 ±2.11 ng/ml (range 6.89- 10.77), daily average dose I0.63±2.57mg/ kg. Adverse effects were observed in 7 patients. Average side effect dose was 14.0 ±3.3 mg/kg and 1275±125 mg (p<00l), serum level was 9.4±2.2 ng/ml. One patient had skin rash, drowsiness, ataxia, tremor, diplopia, vomiting and headache. However those syndromes were disappeared when dose of the drug was reduced. Adverse effects registration was performed. Key words: carbamazepine. therapeutic drug monitoring, partial CONCLUSIONS seizure our results clearly demonstrates that is no difference of the response of Carbamazepine between Mongolian patients and patients from other Asian and Western country. The study has been approved at
ABSTRACT
To determine carbamazepine pharmacokinetic parameters, define seizure stop dose for partial seizure and monitor carbamazepine effect by EEG